Recent Scientific Publications

Full List of Publications

January 15, 2013
Tolerance Induction in HLA Disparate Living Donor Kidney Transplantation by Donor Stem Cell Infusion: Durable Chimerism Predicts Outcome

We recently reported that durable chimerism can be safely established in mismatched kidney recipients through nonmyeloablative conditioning followed by infusion of a facilitating cell (FC)-based hematopoietic stem cell transplantation termed FCRx. Here we provide intermediate-term follow-up on this phase II trial.

Read More

August 20, 2012
Evolving Approaches of Hematopoietic Stem Cell-Based Therapies to Induce Tolerance to Organ Transplants: The Long Road to Tolerance

The immunoregulatory properties of hematopoietic stem cells (HSCs) have been recognized for more than 60 years, beginning in 1945, when Owen reported that genetically disparate freemartin cattle sharing a common placenta were red blood cell chimeras. In 1953, Billingham, Brent, and Medawar demonstrated that murine neonatal chimeras prepared by infusion of donor-derived hematopoietic cells exhibited donor-specific tolerance to skin allografts...

Read More

March 8, 2012
Chimerism and Tolerance Without GVHD or Engraftment Syndrome in HLA-Mismatched Combined Kidney and Hematopietic Stem Cell Transplantation

According to Greek mythology, the Chimera was a fire-breathing creature made of parts from different animals:the body of lioness,a snake's head at the end of the tail and the head of the goat. Sightings of this fearsome beast portended any of a number of terrible disasters. In the context of organ transplantation, a ''chimera'' can indicate both desirable and disastrous outcomes...

Read More

March 7, 2012
The Quest for Transplantation Tolerance: Have We Finally Sipped from the Cup?
- James F. Markmann and Tatsuo Kawai

It is with this firm scientific foundation that experimental protocols were initiated to attempt human kidney transplant acceptance through donor hematopoietic chimerism with only nonmyeloablative conditioning. Three groups have now reported success: one apparently only successful in HLA-matched donor-recipient pairs(7) and two succeeding even in the more challenging situation of pairs disparate for HLA antigens. The first to succeed, Kawai et al., reportedfour of five patients who gained stable immunosuppression-free kidney graft survival now 5.5 to 9.5 years after transplant (8)...

Read More