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Publications

Goode I, Xu H, Ildstad ST.  Regulatory B Cells: the new “it” cell. Transplant Proc. 2013 Nov 8. pii: S0041-1345(13)00880-4.  http://www.ncbi.nlm.nih.gov/pubmed/24216174

Xu H, Yan J, Zhu Z, Hussain L-R, Huang Y, Ding C, Bozulic LD, Wen Y, Ildstad ST.  A critical role for the TLR4/TRIF pathway in allogeneic hematopoietic cell rejection by innate immune cells.  Cell Transplant. 2013;22(12):2367-80.  http://www.ncbi.nlm.nih.gov/pubmed/23146386

 Xu H, Ramsey DM, Bozulic LD, Ildstad ST.  Simultaneous bone marrow and composite tissue transplantation in rats treated with nonmyeloablative conditioning promotes tolerance.  Transplantation 2013; 95(2):301-8. http://www.ncbi.nlm.nih.gov/pubmed/23250336

Ravindra K, Leventhal J, Song D, Ildstad ST.  Chimerism and Tolerance in Solid Organ Transplantation.  Journal of Clinical and Cellular Immunology S9:003, 2012.  http://www.omicsonline.org/chimerism-and-tolerance-in-solid-organ-transplantation-2155-9899.S9-003.php?aid=9316

Leventhal J, Miller J, Abecassis M, Tollerud DJ, Ildstad ST.  Evolving approaches of hematopoietic stem cell-based therapies to induce tolerance to organ transplants:  the long road to tolerance.  Journal of Clinical Pharmacology and Therapeutics 2012; 93(1):36-45. http://www.ncbi.nlm.nih.gov/pubmed/23212110

Leventhal J, Abecassis M, Miller J, Gallon L, Tollerud D, King B, Elliott MJ, Bozulic LD, Houston C, Ildstad ST.  Tolerance induction in HLA disparate living donor kidney transplantation by donor stem cell infusion: durable chimerism predicts outcome.  Transplantation. 2013 Jan 15;95(1):169-76. http://www.ncbi.nlm.nih.gov/pubmed/23222893

Ravindra KV, Xu H, Bozulic LD, Song DD, Ildstad ST.  The need for inducing tolerance in vascularized composite allotransplantation.  Clinical and Developmental Immunology 2012 Nov; 2012:1-11.  http://www.ncbi.nlm.nih.gov/pubmed/23251216

Xu H, Ildstad ST.  Transplantation: Is donor T cell engraftment a biomarker for tolerance? Nature Reviews Nephrology 2012; Oct; 8(10):560-561. http://www.ncbi.nlm.nih.gov/pubmed/22868709

Chen B, Xu H, Corbin DR, Ildstad ST.  A clinically feasible approach to induce delayed tolerance in recipients of prior kidney and vascular composite allotransplants. Transplantation 2012 Oct; 94(7):671-678.   http://www.ncbi.nlm.nih.gov/pubmed/22948444

Leventhal J, Huang Y, Xu H, Goode I, Ildstad ST.  Novel regulatory therapies for treatment and prevention of GVHD.  BMC Medicine 2012 May; 10:48. http://www.ncbi.nlm.nih.gov/pubmed/22587383

Pomahac B, Becker YT, Cendales L, Ildstad ST, Li X, Schneeberger S, Siemionow M, Thomson AW, Zheng XX, and S.G. Tullius.  Vascularized Composite Allotransplantation Research: The Emerging Field. A position paper of the American Society of Transplantation. American Journal of Transplantation 2012 Apr;12(4):1062-1063.  http://www.ncbi.nlm.nih.gov/pubmed/?term=Ildstad+St+Pomahac

Ravindra K, Haeberle M, Levin LS, Ildstad ST.  Immunology of vascularized composite allotransplantation: a primer for hand surgeons.  The Journal of Hand Surgery 2012 Apr; 37(4):842-850. http://www.ncbi.nlm.nih.gov/pubmed/22464235

Xu H, Zhu Z, Huang Y, Bozulic LD, Hussain L-R, Yan J, Ildstad ST.  Innate and Adaptive Immune Responses Are Tolerized in Chimeras Prepared with Non-Myeloablative Conditioning. Transplantation 2012 Mar 15;93(5):469-76. http://www.ncbi.nlm.nih.gov/pubmed/22228418

Leventhal J, Abecassis M, Miller J. Gallon L, Ravindra K, Tollerud DJ, King B, Herzig G, Herzig R, Ildstad ST.  Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation.  Science Translational Medicine 2012 Mar 7; 4(124): 124ra28.  http://www.ncbi.nlm.nih.gov/pubmed/22399264

Guo Y, Sanganalmath SK, Wu W, Zhu X, Huang Y, Tan W, Ildstad ST, Li Q, Bolli R. Identification of inducible nitric oxide synthase in peripheral blood cells as a mediator of myocardial ischemia/reperfusion injury. Basic Research in Cardiology 2012;107(2):1-8. http://www.ncbi.nlm.nih.gov/pubmed/22351077

Ravindra K, Xu H, Ildstad ST.  Vascularized composite allotransplantation (VCA) at a cross roads.  Transplantation Proceedings 2011; 43(9):3501-3. http://www.ncbi.nlm.nih.gov/pubmed/22099829

Cardenas PA, Huang Y, Ildstad ST.  The role of pDC, recipient Treg, and donor Treg in HSC engraftment:  Mechanisms of Facilitation. Chimerism 2011; 2(3):65-70. Epub 2011 Jul 1.  http://www.ncbi.nlm.nih.gov/pubmed/22163063

Ravindra KV, Ildstad ST.  Immunosuppressive protocols and immunological challenges related to hand transplantation.  Hand Clinics 2011; 27:467-479. http://www.ncbi.nlm.nih.gov/pubmed/?term=Ildstad+St+Hand+Clinics+2011

Wu S, Xu H, Chen B, Wen Y, Ikusika OM, Ocker A, Zhao H, Ildstad ST.  Sensitized recipients exhibit accelerated but not hyperacute rejection of vascularized composite tissue allografts.  Transplantation 2011; 92(6):627-633.  http://www.ncbi.nlm.nih.gov/pubmed/21822173

Bozulic LD, Huang Y, Xu Y, Wen Y, Ildstad ST.  Differential Outcomes in Pre-diabetic vs. Overtly Diabetic NOD Mice Nonmyeloablatively Conditioned with Co-stimulatory Blockade.  Experimental Hematology 2011; 39:977-985.  http://www.ncbi.nlm.nih.gov/pubmed/21726515

Ildstad ST, Shirwan H, Leventhal J.  Is durable macrochimerism key to achieving clinical transplantation tolerance?  Curr Opin Organ Transplant. 2011 Aug;16(4): 343-4. http://www.ncbi.nlm.nih.gov/pubmed/?term=Ildstad+St+Shirwan+H%2C+Leventhal+J

Bozulic LD, Wen Y, Xu H, Ildstad ST.  Evidence that FoxP3+ Treg may play a role in promoting long-term acceptance of CTA.  Transplantation, 2011; 91(8):908-915. http://www.ncbi.nlm.nih.gov/pubmed/21304439

Huang Y, Bozulic LD, Miller T, Xu H, Hussain L-R, Ildstad ST.  CD8α+ plasmacytoid precursor DC induce antigen-specific regulatory T cells that enhance HSC engraftment in vivo.  Blood. 2011 Feb 24;117(8):2494-505.  http://www.ncbi.nlm.nih.gov/pubmed/21190989

Wen Y, Chen Bo, Ildstad ST.  Stem cell-based strategies for the treatment of Type 1 diabetes mellitus. Expert Opinion on Biological Therapy, 2011: 11(1):41-53. http://www.ncbi.nlm.nih.gov/pubmed/21110785

Huang Y, Enzmann V, Ildstad ST.  Stem cell-based therapeutic applications in retinal degenerative diseases.  Stem Cell Reviews and Reports, 2011; 7:434-445.  http://www.ncbi.nlm.nih.gov/pubmed/20859770

Huang Y, Ildstad ST.   A novel role of innate immune responses (TLR-4) in triggering GVHD. Transplantation, 2010; 90(10):1052-1053.  http://www.ncbi.nlm.nih.gov/pubmed/20844466

Xu H, Huang Y, Hussain L-R, Zhu Z, Bozulic LD, Yan J, Ildstad ST.  Sensitization to minor antigens is a significant barrier in transplantation and is prevented by CD154:CD40 blockade.  American Journal of Transplantation, 2010: 10(7):1569-1579. http://www.ncbi.nlm.nih.gov/pubmed/20642683

Huang Y, Kucia M, Hussain L-R, Wen Y, Xu H, Yan J, Ratajczak MZ, Ildstad ST. Bone marrow transplantation temporarily improves pancreatic function in streptozotocin-induced diabetes: potential involvement of VSEL cells.  Transplantation, 2010: 89(6):677-685.  http://www.ncbi.nlm.nih.gov/pubmed/20110858

Ding C, Cai Y, Marroquin J, Ildstad ST, Yan J.  Plasmacytoid dendritic cells regulate autoreactive B cell activation via soluble factors and in a cell-to-cell contact manner.  Journal of Immunology, 2009 Dec 1;183(11):7140-9. http://www.ncbi.nlm.nih.gov/pubmed/19890051
Rahhal DN, Xu H, Huang W-C, Wu S, Huang Y, Ildstad ST. Dissociation between peripheral blood chimerism and tolerance to hindlimb composite tissue transplants:  preferential localization of chimerism in donor bone.  Transplantation 2009: 88(6):773-81.  http://www.ncbi.nlm.nih.gov/pubmed/19920776

Sanganalmath SK,  Stein AB, Guo Y, Tiwari S, Hunt G, Vincent RJ, Huang Y, Rezazadeh A, Ildstad ST, Dawn B, Bolli R. The beneficial effects of postinfarct cytokine combination therapy are sustained during long-term follow-up.  Journal of Molecular and Cellular Cardiology 2009;47(4):528-35. http://www.ncbi.nlm.nih.gov/pubmed/19616005

Ravindra KV, Wu S, McKinney M, Xu H, Ildstad ST.  Composite tissue allotransplantation:  current challenges.  Transplantation Proceedings 2009; 41(9):3519-3528.  http://www.ncbi.nlm.nih.gov/pubmed/19917338

Enzmann V, Yolcu E, Kaplan HJ, Ildstad ST.  Stem cells as tools in regenerative therapy for retinal degeneration.  Archives of Ophthalmology 2009; 127(4):563-571. http://www.ncbi.nlm.nih.gov/pubmed/19365041

Tobin GR, Breidenbach WC, Ildstad ST, Marvin MM, Buell JF, and Ravindra KV.  The history of human composite tissue allotransplantation.  Transplantation Proceedings 2009; 41(2):466-71.  http://www.ncbi.nlm.nih.gov/pubmed/19328905

Wu S, Xu H, Ravindra K, Ildstad ST.  Composite Tissue Allotransplantation: Past, Present and Future – the History and Expanding Applications of CTA as a New Frontier in Transplantation. Transplantation Proceedings 2009; 41(2):463-5.  http://www.ncbi.nlm.nih.gov/pubmed/19328904

Xu H, Huang Y, Chilton PM, Hussain L-R, Tanner MK, Yan J, Ildstad ST.  Strategic nonmyeloablative conditioning:  CD154:CD40 co-stimulatory blockade at primary BMT promotes engraftment for secondary BMT after engraftment failure.  Journal of Immunology 2008; 181(9):6616-24.  http://www.ncbi.nlm.nih.gov/pubmed/18941252

Swearingen B, Ravindra K, Xu H, Wu S, Breidenbach WC, Ildstad ST.  The Science of Composite Tissue Allotransplantation.  Transplantation 2008; 86(5):627-635.  http://www.ncbi.nlm.nih.gov/pubmed/18791440

Huang Y, Fugier-Vivier IJ, Miller T, Elliott MJ, Xu H, Bozulic L, Chilton PM, Ildstad ST.  Plasmacytoid precursor dendritic cells from NOD mice exhibit impaired function:  are they a component of diabetes pathogenesis?  Diabetes 2008; 57(9):2360-70. http://www.ncbi.nlm.nih.gov/pubmed/18567821

Huang Y, Ratajczak MZ, Reca R, Xu H, Tanner M, Rezzoug F, Hussain L-R, Fugier-Vivier I, Bolli R, Ildstad ST.  Fms-related tyronsine kinase 3 (Flt3) expression discriminates hematopoietic stem cells subpopulations with differing engraftment-potential: identifying the most potent combination.  Transplantation 2008; 85(8): 1175-1184.  http://www.ncbi.nlm.nih.gov/pubmed/18431239

Ravindra KV, Wu S, Bozulic L, Xu H, Breidenbach WC, Ildstad ST. Composite Tissue Transplantation:  A Rapidly Advancing Field.  Transplantation Proceedings 2008; 40(5):1237-48. http://www.ncbi.nlm.nih.gov/pubmed/18589081

Xu H, Yan J, Huang Y, Chilton PM, Ding C, Schanie CL, Wang L, Ildstad ST.  Co-stimulatory blockade of CD154:CD40 in combination with T-cell lymphodepletion results in prevention of allogeneic sensitization.  Blood 2008; 111:3266-3275.  http://www.ncbi.nlm.nih.gov/pubmed/17827394

Rezzoug F, Huang Y, Tanner MK, Wysoczynski M, Schanie CL, Chilton PM, Ratajczak MZ, Fugier-Vivier IJ, Ildstad ST.  TNFα is critical to facilitation of hematopoietic stem cell engraftment and function. Journal of Immunology 2008; 180:49-57. http://www.ncbi.nlm.nih.gov/pubmed/18097003

Xu H, Chilton PM, Tanner MK, Huang Y, Schanie CL, Dy-Liacco M, Yan J, Ildstad ST.  Humoral immunity is the dominant barrier for allogeneic bone marrow engraftment in sensitized recipients.  Blood 2006; 108(10): 3611-3619.  http://www.ncbi.nlm.nih.gov/pubmed/16888094

Huang Y, Kucia M, Rezzoug F, Ratajczak J, Tanner M, Ratajczak MZ, Schanie CL, Xu H, Fugier-Vivier IJ, Ildstad ST.  Flt3-ligand-mobilized peripheral blood, but not Flt3-ligand-expanded bone marrow, facilitating cells promote establishment of chimerism and tolerance.  Stem Cells 2006; 24: 936-948.  http://www.ncbi.nlm.nih.gov/pubmed/16644924

Ildstad ST, Chilton PM, Xu H, Domenick MA, Kosiewicz MM, Ray MB.  Preconditioning of NOD mice with anti-CD8 mAb and co-stimulatory blockade enhances chimerism and tolerance and prevents diabetes while depletion of αβ-TCR+ and CD4+ cells negates the effect.  Blood 2005; 105: 2577-2584. http://www.ncbi.nlm.nih.gov/pubmed/15498851

Fugier-Vivier IJ, Rezzoug F, Huang Y,  Graul-Layman AJ , Schanie CL , Xu H, Chilton PM, Ildstad ST.  Plasmacytoid precursor dendritic cells play an integral role in facilitating allogeneic hematopoietic stem cell engraftment and tolerance induction.  Journal of Experimental Medicine 2005; 201(3):373-383.  http://www.ncbi.nlm.nih.gov/pubmed/15699072

Chilton PM, Rezzoug F, Ratajczak MZ, Fugier-Vivier I, Ratajczak J, Kucia M, Huang Y, Tanner MK, Ildstad ST.  Hematopoietic stem cells from NOD mice exhibit autonomous behavior and a competitive advantage in allogeneic recipients. Blood 2005; 105(5):2189-2197. http://www.ncbi.nlm.nih.gov/sites/entrez/15522953

Chilton PM, Rezzoug F, Fugier-Vivier I, Weeter LA, Xu H, Huang Y, Ray MB, Ildstad ST.  FLT-3 ligand treatment prevents diabetes in NOD mice. Diabetes 2004; 53(8):1995-2002. http://www.ncbi.nlm.nih.gov/pubmed/15277378

Huang Y, Rezzoug F, Chilton PM, Grimes HL, Cramer DE, Ildstad ST.  Matching at the MHC class I K locus is essential for long-term engraftment of purified hematopoietic stem cells:  a role for host NK cells in regulating HSC engraftment.  Blood 2004; 104(3):873-880. http://www.ncbi.nlm.nih.gov/pubmed/15054040

Yaroslavskiy B, Colson Y, Ildstad ST, Parrish D, Boggs SS.  Addition of a bone marrow “facilitating cell” population increases stem cell-derived cobblestone area formation in impaired long-term bone marrow culture stroma. Experimental Hematology 1998; 26:604-611. http://www.ncbi.nlm.nih.gov/pubmed/?term=Ildstad+St+Yaroslavskiy+B%2C+Colson+Y%2C

Colson YL, Lange J, Fowler K, Ildstad ST.  Mechanism for co-tolerance in nonlethally conditioned mixed chimeras: Negative selection of the Vβ-T-cell receptor repertoire by both host and donor bone marrow-derived cells.  Blood 1996; 88(12):4601-4610. http://www.ncbi.nlm.nih.gov/pubmed/?term=Ildstad+St+Colson+YL%2C+Lange+J%2C+Fowler+K%2C

Kaufman CL, Colson YL, Wren SM, Watkins S, Simmons RL, Ildstad ST.  Phenotypic characterization of a novel bone marrow derive- cell that facilitates engraftment of allogeneic bone marrow stem cells.  Blood 1994; 84(8):2436-2446. http://www.ncbi.nlm.nih.gov/pubmed/?term=Ildstad+St+Kaufman+CL%2C+Colson+YL%2C+Wren+SM%2C

Ildstad ST, Wren SM, Boggs SS, Hronakes ML, Vecchini F, Van den Brink MRM.  Cross species bone marrow transplantation:  Evidence for tolerance induction, stem cell engraftment, and maturation of T-lymphocytes in a xenogeneic stromal environment (rat → mouse).  Journal of Experimental Medicine 1991; 174:467-478. http://www.ncbi.nlm.nih.gov/pubmed/1856629

Ildstad ST, Bluestone JA, Sachs DH.  Alloresistance to engraftment of allogeneic donor bone marrow is mediated by an Lyt2+ T cell in mixed allogeneic reconstitution (C57BL/10Sn + B10.D2/nSn → C56BL/10Sn).  Journal of Experimental Medicine 1986; 163:1343-1348. http://www.ncbi.nlm.nih.gov/pubmed/2939173

Ildstad ST, Sachs DH.  Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts.  Nature 1984; 307:168-170.  http://www.ncbi.nlm.nih.gov/pubmed/6361574